Supplementary Report: Normalization of oligonucleotide ar- rays based on the least-variant set of genes
نویسنده
چکیده
Figure S1: Plot of the t-statistic versus the log standard-error for RMA expression values of the Golden-Spike data normalized using different methods. All normalization were performed after summarization of probe intensities. The FC1-based normalizations are ideal, and in real nonspike-in studies are not possible. LVS-normalization is closest to the FC1-based normalization. The others show negative bias for FC1 genes and suppressed values for genes with FC≥ 2.
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